Scientific Program - 3rd International Congress on Deuterium Depletion

7 May 2015
Thursday 10:30-12:00

  • Workshop: 1H and 13C Roadmaps for Nuclear Magnetic Resonance Spectroscopy - Methods, Standards and Applications

  • Chairs: Prof. Dr. Justine P. Roth (Johns Hopkins University, USA)
    Dr. Csilla Ari (University of South Florida, USA)


  • 10:30-11:00
    NMR applications for Systems Biology and Metabolic Profiling: Why standardized methods are called for
    Prof. Dr. Ulrich L. Günther

    Professor of Biophysical Chemistry and Scientific Director, The Henry Wellcome Building for Biomolecular NMR, School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK, EU

  • 11:00-11:30
    Biochemical interpretations of 2H/1H ratio contrast magnetic resonance spectroscopy: tissue phenotyping by mitochondrial matrix (metabolic 1H2O) and cytoplasmic (2H1HO) water ratios in cells
    Prof. Dr. László G. Boros

    Professor of Pediatrics and Chief Scientific Advisor, SiDMAP, LLC, Department of Pediatrics, University of California Los Angeles (UCLA) School of Medicine and The Los Angeles Biomedical Research Institute (LABIOMED), Torrance, CA, USA

  • 11:30-12:00
    Magnetic Resonance Imaging - its Added Value in Clinical Diagnostic Procedures and Future Trends
    Dr. András Vargha

    Chair, National Quality Standards and Clinical Audits, Radiology, Budapest, Hungary, EU

3rd International Congress on Deuterium Depletion

14:00 Opening remarks (To be announced)

  • Afternoon Session: Kinetic Isotope Effects and Biological Chemistry of Deuterium Depletion (14:00-17:30)

  • Chairs: Prof. Dr. Ulrich Günther (University of Birmingham, UK, EU)
    To Be Announced


  • 14:10-15:00
    Anomalous Deuterium Kinetic Isotope Effects on Fatty Acid Oxidation: Implications for Isotope Discrimination in Biology
    Prof. Dr. Justine P. Roth

    Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA

  • 15:00-15:20
    Escherichia coli growth rate measurements verify the Isotopic Resonance Hypothesis
    Prof. Dr. Roman Zubarev

    Karolinska Institute, Stockholm, Sweden, EU

  • 15:20-15:40
    Some Physico-Chemical Properties of Deuterium Depleted Water
    Prof. Dr. Valentin Lobyshev

    Physical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

  • 15:40-16:00 Coffee break

  • Afternoon Session Continued:

  • Chairs: Prof. Dr. Valentin Lobyshev (Lomonosov University, Moscow, RF)
    To Be Announced


  • 16:00-16:20
    Physico-chemical properties of DDW as its quality indicators for pharmaceutical analysis practice
    Dr. Mariya Morozova

    Peoples’ Friendship University of Russia, Moscow, Russian Federation

  • 16:20-16:40
    Influence of deuterium depleted water on freeze dried tissue isotopic composition and morphofunctional body performance in rats of different generations
    Prof. Dr. Stephan Dzhimak

    Kuban State University, Krasnodar, Russian Federation

  • 16:40-17:00
    Influence of deuterium depleted water on biological activity/Toxicity components of pharmaceuticals
    Olga Titorovich

    Peoples’ Friendship University of Russia, Moscow, Russian Federation

  • 17:00-17:30 Open Discussion with presenters

  • 18:00 Gala Dinner

8 May 2015
Friday 9:00-16:00 (Day 2)

  • Morning Session: Biochemical aspects and mechanism of action of deuterium depletion

  • Chairs: Dr. Gábor Somlyai (HYD, LLC., Budapest, Hungary, EU)
    Prof. Dr. László G. Boros (UCLA, Los Angeles, CA, USA)


  • 9:00-9:50
    Non-toxic metabolic management of metastatic cancer: Novel combination of ketogenic diet, ketone supplementation, and hyperbaric oxygen therapy
    Dr. Dominic P. D’Agostino

    Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, Hyperbaric Biomedical Research Laboratory, University of South Florida, Tampa, FL

  • 9:50-10:10
    Neuroprotective Metabolic Therapies by Ketogenic Enhancement of the Szentgyörgyi-Krebs Cycle: Studies in Animal Models
    Dr. Csilla Ari

    Department of Molecular Pharmacology and Physiology, Hyperbaric Biomedical Research Laboratory, Morsani College of Medicine, University of South Florida, Tampa FL, USA

  • 10:10-10:30 Coffee break

  • Chairs: Prof. Dr. Roman Zubarev (Karolinska Institute, Stockholm, Sweden EU)
    To Be Announced


  • 10:30-10:50
    Deuterium content of water and glucose tolerance: potential role for the prevalence of affective disturbances
    Dr. Brandon Cline

    INSERM University of Strasbourg, Strasbourg, France

  • 10:50-11:10
    Effect of deuterium depletion on glucose tolerance, serum HDL- and Na+-concentration
    Dr. Gábor Somlyai

    HYD LLC for Cancer Research and Drug Development, Budapest, Hungary, EU

  • 11:10-11:30
    Isotopic effects of deuterium in water on respiration rate, phosphorylation and hydrogen peroxide generation by rat liver mitochondria
    Prof. Dr. Valentin Lobyshev

    Physical Faculty, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

  • 11:30-11:50
    Biochemistry of metabolic tracers for Systems Biology, phenotype testing and drug research
    Prof. Dr. Marta Cascante

    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Catalonia, Spain, EU

  • 12:00-13:00 Lunch

  • Afternoon Session: Biological and clinical applications of deuterium depletion

  • Chairs: Dr. Brandon Cline (INSERM, Strasbourg, France, EU)
    Dr. Dominic P. D’Agostino (University of South Florida, USA)


  • 13:00-13:50
    Gluconeogenesis and the pentose cycle impact deuterium depleted water efficacy in anticancer therapeutics
    Prof. Dr. László G. Boros

    Department of Pediatrics, Harbor-UCLA Medical Center, UCLA School of Medicine, Los Angeles, The Los Angeles Biomedical Research Institute (LABiOMED), Torrance, California, and SIDMAP, LLC, Culver city, CA, USA

  • 13:50-14:10
    Effect of reduced deuterium concentration of water on germination, shoot and root development, as well as on SOD and CAT isoenzyme patterns of wheat and sunflower
    Dr. Balázs Barna

    Plant Protection Institute, Research Centre for Agriculture, Hungarian Academy of Sciences

  • 14:10-14:30 Coffee break

  • Chairs: To Be Announced


  • 14:30-14:50
    Deuterium as a risk factor for mental disorders
    Prof. Dr. Igor Pomytkin

    ZAO Legkaya voda, Moscow, Russian Federation

  • 14:50-15:40
    Deuterium depletion results in several fold increases in the median survival time of cancer patients during oncotherapy
    Dr. Gábor Somlyai

    HYD LLC for Cancer Research and Drug Development, Budapest, Hungary, EU

  • 15:40-16:10 Discussions, Closing Remarks - Meeting Adjourned